Derbyshire will take Twenty20 cricket to Staffordshire in June when they meet Warwickshire at Leek.
Derbyshire staged a 40-over game with Essex at Highfield last season and have now committed to play the FP t20 tie there on Sunday, 26 June.
Chief executive Keith Loring said: "Playing at Leek last season demonstrated to our match-day operation could be performed at the venue.
"The public produced an excellent response. They deserve this."
Leek cricket club chairman Brian Mellor said: "This fixture will provide an excellent opportunity for the people of Leek, Staffordshire Moorlands and Stoke-on-Trent to witness Twenty20 cricket close to home.
"Twenty20 has become one of the most popular spectator sports in the world and it is a great thrill that we are now looking forward to hosting such a high profile match at Highfield."