Prince was out for a duck when the sides previously met in the competition
Ashwell Prince hit his first one-day half-century of the season to steer Lancashire to a six-wicket FP Trophy victory over Northants at Old Trafford.
The South African struck 78, Paul Horton 46 and Francois du Plessis an unbeaten 40 to steer Lancashire comfortably past the visitors' 212-9.
That looked more than Northants might make after being reduced to 129-7 despite 50 from Nicky Boje.
But Alex Wakeley and David Lucas hit 32 each to guide them to respectability.
The victory, secured with 15 balls to spare, was Lancashire's fourth in five games in the competition this season and saw them stay neck and neck with Essex at the top of Group D.
It might have been even easier had Lancashire not conceded 33 extras and allowed Lucas and Wakeley had 40 for the eighth wicket, before Lucas and Lee Daggett added an unbroken 41 for the final wicket in eight overs.
Lancashire's reply got off the worst possible start when Tom Smith was dismissed with only three on the board.
But Prince and Horton added 97 for the second wicket to put Lancashire in charge.
It was a welcome return to form in the one-day game for Prince, who is averaging 98.75 in the County Championship, but who's previous highest score in this season's FP Trophy was 44.
He departed with victory in sight, caught at deep midwicket by David Willey off Daggett, but du Plessis and Steven Croft saw them over the line.
Ashwell Prince told BBC Radio Lancashire:
"It was important that we picked ourselves up after not a great display on Sunday (in losing to Essex).
"The guys have shown great character to start well with the ball and then finish it off with the bat.
"It's important to be strong mentally because there are a lot of games on top of each other and there can be some tired bodies out there when you have long bus drives in between.
"Once the match starts you need to be fresh mentally and tuned in, and the guys showed they were there today."
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