Klitschko defended his titles against Samuel Peter in September
World heavyweight champion Wladimir Klitschko will defend his IBF, IBO and WBO titles against Briton Dereck Chisora on 11 December.
Chisora, 26, beat Sam Sexton in September to add the Commonwealth heavyweight title to his British crown.
"I knew that my win against Sexton would lift me in the ranking but this is a surprise," said Chisora.
Ukrainian Klitschko, 34, has a record of 55 wins and three losses, while Chisora has won all of his 14 fights.
Klitschko's older brother Vitali will defend his WBC crown against American Shannon Briggs on Saturday.
The WBA belt is held by David Haye, who will defend his title for the second time against fellow Briton Audley Harrison in Manchester on 13 November.
"Chisora is young, quick and a hard puncher," stated Wladimir Klitschko.
"My coach Emanuel Steward has warned me of his qualities and reminded me of the 1978 defeat of the great Muhammad Ali by the 24-year-old Leon Spinks. I will try not to give Chisora a single chance."