Mayweather Sr has trained the likes of Oscar de la Hoya
Ricky Hatton will be trained by Floyd Mayweather Sr for his fight against IBF light-welterweight champion Paulie Malignaggi in Las Vegas on 22 November.
The American is father to Floyd Jr - who beat Hatton in 2007 - and will fly into Manchester later in September.
The 55-year-old will be assisted by close friend Lee Beard, a key member of Team Hatton for more than a year.
Billy Graham, Hatton's trainer for 11 years, retired on 1 August, and claimed to have been sacked by the Hatton team.
But he added at the time: "It's not over between me and Ricky just because I'm not training him any more.
"I'll be there and I'll be urging him on. I just won't be in his corner - that's the only difference."
Mayweather Sr and his son, the only fighter to have beaten Hatton, do not see eye to eye, with Mayweather Jr preferring to work with his uncle Roger - also a trainer - for most of his career.
After winning his first world title belt in 1998, the boxer, who announced his retirement from boxing in June, dismissed his father in a bitter falling-out and the pair did not speak for seven years.
Mayweather Sr has trained boxers such as Oscar de la Hoya, Joan Guzman and Chad Dawson in addition to his son.