Ronald "Winky" Wright's trainer, Dan Birmingham, has welcomed Joe Calzaghe's assertion the two fighters could meet in the first half of 2008.
Wright is one of the leading pound-for-pound fighters in the world
With Calzaghe's top target, Bernard Hopkins, unlikely to face him until summer 2008, the Welshman has targeted a major fight in March or April.
He has put forward Wright's name and Birmingham is keen on the match.
"It could definitely be made and it would be a truly great match-up," Birmingham told BBC Sport Wales.
American Wright, 36, was a long-reigning light-middleweight champion, but has moved up in the last two years, battling to a draw with Jermain Taylor at middleweight and losing to Bernard Hopkins at light-heavyweight in his last bout.
Undisputed super-middleweight champion Calzaghe, 35, is eager to move up a division as he plans a final year in the sport, but would be more likely to meet Wright at 168lbs, possibly at Cardiff's Millennium Stadium.
"It would be an honour and a pleasure for us to come over there and face Joe, who I consider one of the best pound-for-pound fighters in the world," said Birmingham.
"It would have to be on the right terms and at the right weight. Winky was too heavy against Hopkins and it was an ugly fight.
"The two southpaws would match up well. Winky has really good hand speed and movement and a lot of experience.
It would be good to come over with Winky and try to get some payback
"He only wants the big fights and there aren't many bigger than Calzaghe.
"Calzaghe is a master of distance and timing, with great speed, chin and heart.
"He doesn't look intimidating, but when he gets into the ring he always takes care of business. I have a lot of respect for him."
Birmingham was in the corner opposing Calzaghe for one of the landmark victories of the Welshman's undefeated career, last year's stunning win over Jeff Lacy.
Birmingham described the performance on the night as "the best I've ever seen".
Wright, whose record stands at 51-4-1 (25 KOs), is from the same town as Lacy - St Petersburg, Florida - and helped his compatriot in preparation for the Calzaghe bout.
Afterwards, he spoke of being keen to face the Welshman to gain revenge for his friend, a sentiment now echoed by his trainer.
"It would be good to come over with Winky and try to get some payback," said Birmingham.
"Winky is used to fighting overseas, so coming to the UK would not be a problem.
"We know all about what Calzaghe can do, but he should be concerned about what Winky can do."