Castillejo was trailing on points before stopping Sturm
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Javier Castillejo stopped Felix Sturm in the 10th round of their middleweight fight to win the WBA title in Hamburg.
Sturm, making his first defence, was on his way to a points win until Spaniard Castillejo caught him with a left hook with 13 seconds left in the round.
Castillejo then landed three uppercuts before the referee stopped the fight.
Sturm was taken to hospital with a suspected broken jaw which may have happened when he was knocked down in the second round.
In other fights on the Hamburg card, Wladimir Sidorenko of Ukraine defended his WBA bantamweight title with a unanimous decision over Thai Poonsawat Kratingdaenggym.
Ukraine's Vladimir Virchis took the European heavyweight title from Paolo Vidoz with a sixth-round stoppage.
Britain's Michael Sprott failed in his challenge for the WBA inter-continental heavyweight title when he was stopped in the eighth round by Ruslan Chagaev of Uzbekistan.