Manchester Great City Games
Date: 16 May Coverage: Great Manchester Run 1000-1130 BST & Great City Games 1630-1800 BST live on BBC Two and BBC Sport website (UK users only)
Ohuruogu finished second last year, while Ennis will make her debut in May
Olympic 400m champion Christine Ohuruogu will take on world heptathlon champion Jessica Ennis over 150m at the Manchester Great City Games in May.
Beijing gold medallist Ohuruogu came second in last year's inaugural Games, with Jamaican sprint sensation Usain Bolt winning the men's event.
"The Great City Games was a brilliant event - a 150m track laid in the middle of the city," said Ohuruogu.
"Despite the weather the atmosphere was great as the crowd really got into it."
Bolt, who set a new world best in Manchester, will not feature this year but world 100m silver medallist Tyson Gay and world 200m silver medallist Alonso Edwards will race on the specially erected track on 16 May.
American Gay has not confirmed what distance he will run, but Edwards has confirmed he will race in the 150m, the distance over which Bolt set a world best of 14.35sec in last year's race.
Debbie Ferguson of the Bahamas, who beat Ohuruogu last year, will compete against the 2009 IAAF World Athlete of the Year, Sania Richards, in the 200m as well as Scotland's Lee McConnell.
Ohuruogu posted a British record 17.10 seconds at the event before lowering it to 16.94s at the Great North City Games in September and will compete at the Penn Relays in Philadelphia next weekend.
There will also be an opportunity for members of the public to race over the 150m distance in the
Great Manchester 150
on Saturday 15 May.