Astin led the women's under 17 event from start to finish.
Manx Harriers won six medals at the Lancashire Cross Country Championships in Blackburn on Saturday.
Gemma Astin led the U17 women's event from start to finish to claim gold.
There was disappointment, however, for defending champion Keith Gerrard and the Manx Harriers men's team who narrowly missed out on gold medals.
The senior men's team brought home silver with Nigel Armstrong, Chris Quine and Andy Fox all winning bronze medals in their age groups.
Defending champion Gerrard, who recently finished seventh in the European Under-23 Championships, also claimed bronze.
Team manager Andy Fox told BBC Isle of Man: "The frozen ground was very treacherous and Keith couldn't risk running flat out on the frozen rutted downhill sections."
He added: "Despite getting 11 men in the top 31 in the county, we couldn't match Blackburn Harriers in the team event where the top six count."
Results, 10 January
Senior Men: Silver
Keith Gerrard 3rd, Kevin Loundes 5th, Darren Gray 7th, Martin Malone 18th, Nigel Armstrong 20th, Ed Gumbley 23rd, Chris Quine 25th Gianni Epifani 26th, Christian Varley 29th, Murray Lambden 30th, Andy Fox 31st, Russell Collister 45th, Mike Garrett 46th, Robbie Lambden 87th, 94 finishers. Manx Harriers won the Veterans team event
Senior Women Sarah Curphey 16th
Under 20 Men Ben Lambden 9th
Under 17 Women Gemma Astin 1st; Polly Rogerson 7th
Under 15 Girls Sarah Astin 4th; Caitriona Cox 13th
Under 15 Boys Sammy Holt 22nd
Under 13 Girls Alice Ashe 9th; Sosanna Cox 18th
Under 11 Boys Conor Davies 13th
Under 11 Girls Danielle Barton 4th; Katie Astin 5th; Josie McGarrigle 6th