Briton Christine Ohuruogu suffered her third straight defeat to American Sanya Richards since she became world 400m champion in August.
Richards (left) was simply too fast for world champion Ohuruogu
Richards won the event at the World Athletics Final in Stuttgart, from Novlene Williams and then Ohuruogu.
Ohuruogu claimed a podium spot with a late rally to finish in 50.20 seconds, 0.93 seconds behind Richards.
Fellow Brit Nicola Sanders came fifth in their final race of the European season, coming in at 50.44 seconds.
Richards, 23, did not qualify for the American team that competed at the World Championships in Osaka because of illness but has since underlined her status as the top women's 400m runner.
Ohuruogu said: "I saw her come past and it woke me up, got me motivated to run faster.
"I think she's way ahead of the field, but I also think she can be beaten one day and I hope that will be by me."
Ohuruogu will now jet off to the Far East, competing in Shanghai next Friday and then having a short holiday before commencing winter training.
Marilyn Okoro ran the finest 800m race of her career, finishing third in a personal best of 1min 58.76secs.
The race was won by Kenya's world champion Janeth Jepkosgei in 1:57.87, while Spain's Mayte Martinez came third.
"I've been waiting to do that all season and it was a fantastic opportunity for me to do it here," said Okoro of her personal best as she celebrated her 23rd birthday.
Jemma Simpson finished last in the race in 2:00.78., while Germaine Mason ended the season on a strong note, finishing fourth in the high jump with a best effort of 2.27 metres.
Andrew Baddeley claimed seventh in the 1500m in 3:39.14, Daniel Kipchirchir Komen winning a slow race in 3:37.96.
Cuba's Robles was in excellent form in the 110m hurdles
Mo Farah, after finishing third in the previous day's 3,000m final, was seventh over 5,000m in 13:41.61.
Kenya's Edwin Soi, adding to his success over the shorter distance, won in 13:38.16.
The long jump was won by Andrew Howe of Italy, with Chris Tomlinson fifth with a best effort of 7.93m.
Natasha Danvers-Smith came seventh in the 400m hurdles in 55.76 seconds, with Anna Jesien winning the race from Australia's Jane Rawlinson.
Ethiopia's Meseret Defar ran from the front to win the women's 3,000m, beating Vivian Cheruiyot and Priscah Jepleting Cherono of Kenya.
Briton's Helen Clitheroe and Hattie Dean finished seventh and eighth.
Joice Maduaka, clocking 11.61 seonds, was last in the 100m won by the USA's world bronze medallist Carmelita Jeter in 11.10.
Ireland's Paul Hession was outclassed over 200m, finishing last in 20.58. Jaysuma Saidy Ndure won with a Norwegian record of 19.89.
Cuba's Dayron Robles won the 110m hurdles in 12.92 seconds, defeating American trio David Payne, Terrence Trammell and Anwar Moore to put down a marker ahead of next year's Beijing Olympics.
Russian Tatyana Lebedeva had to settle for third place in the triple jump at the World Athletics Final in Stuttgart.
Lebedeva was hoping to follow up her long jump victory on Saturday but Cuba's Yargelis Savigne won with a leap of 14.72m.