Wasps (15) 28
Delon Armitage scored a consolation try for London Irish
Tries: Skivington, Cipriani, Voyce
Cons: Van Gisbergen 2
Pens: Van Gisbergen 3
London Irish (9) 14
Tries: D Armitage
Pens: Hickey 3
Wasps won their first Premiership game of the season to move off the foot of the table on Sunday.
Tries from George Skivington and Daniel Cipriani helped Wasps into a 15-3 lead but two Eoghan Hickey penalties trimmed the gap to six points at the break.
Tom Voyce scored a converted try two minutes after the re-start before Mark van Gisbergen's penalty made it 25-9.
Delon Armitage crossed for the Exiles but Wasps had the last word through Van Gisbergen's third penalty.
Wasps director of rugby Ian McGeechan
"Overall I felt the power to get that result was in our hands, which was nice to feel again.
"Our execution could have been better in places but there were a lot of good things today.
"We didn't build as well as we could, but overall I thought we played well and consistently."
Wasps: Van Gisbergen, Doherty, Waters, Flutey, Voyce, Cipriani, Reddan, Holford, Ward, Barnard, Skivington, Birkett, Leo, Webber, Haskell.
Replacements: Beech, Adams, Ellis, Hart, Amor, Walder, Hoadley.
London Irish: D Armitage, Ojo, Shabbo, Mapusua, Tagicakibau, Hickey, Hodgson, D Murphy, Paice, Lea'aetoa, Kennedy, Casey, Danaher, S Armitage, Thorpe.
Replacements: Dunning, Mackie, Warren, Roche, P Murphy, Fury, Staunton.
Referee: Roy Maybank (Kent)