Iriekpen and Rubiales only played a handful of matches each for Accies
Izzy Iriekpen has had his Hamilton contract cancelled just five weeks after signing a two-year deal.
Fellow defender Luis Rubiales will also leave the club only two weeks since arriving from Spanish club Alicante.
Iriekpen, 27, captained Accies in two of the three matches he played in for them, while 32-year-old Rubiales played four times for Billy Reid's side.
"I did not realise this move would result in such hardship for my family," Iriekpen told the club website.
BBC Scotland understands family reasons are also behind Rubiales' exit.
"After explaining my personal situation to manager Billy Reid, he, Hamilton's front office and I have agreed to an amicable separation," added Iriekpen.
This is the second time Iriekpen has turned his back on Hamilton.
He was on the brink of joining them during the January transfer window, only to change his mind at the last minute and sign for Bristol City.
The U-turn angered Reid but that did not prevent the Accies boss coming back in for the player when he was released by the Robins.
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