Veterans Don Hutchison and Paul Peschisolido hit their first goals for Luton to help dispose of Northampton in the Johnstone's Paint Trophy.
Hutchison swept home from close range in the 12th minute after Calvin Andrew's header from a David Bell corner had been blocked on the line.
Substitute Peschisolido made it 2-0, blasting home Steve Robinson's pass from the edge of the area.
Hatters keeper Dean Brill denied Ryan Ryan Gilligan in the final moments.
Luton: Brill, Keane, Goodall, Perry, Fojut, Hutchison, Bell (McVeigh 21), Robinson, Brkovic, Talbot (Peschisolido 46), Andrew (Morgan 83).
Subs Not Used: Coyne, O'Leary.
Booked: Hutchison, Robinson, Keane.
Goals: Hutchison 12, Peschisolido 48.
Northampton: Bunn, Hughes, Doig (Crowe 28), Dolman, May, Bradley Johnson, Dyer (Gilligan 68), Jones, Russell, Larkin, Hubertz (Kirk 55).
Subs Not Used: Dunn, Holt.
Ref: Ray Lee (Essex).