Radiohead are giving fans the chance to remix Nude, the second single from their latest album, In Rainbows.
The band have split the track into five different parts - voice, guitar, bass, drums and strings. Users can also add their own instruments and effects.
Remixers are sent an access code to transfer the files into music production software like Garageband or Logic Pro.
Finished mixes can be uploaded to a new website - radioheadremix.com - where users vote for their favourite. The winner will be announced on 1 May.
Fans can also copy their version of the track to social networking websites like MySpace and Facebook.
Radiohead have been experimenting with new ways of selling and distributing music since leaving their record label Parlophone.
The band let fans decide how much to pay for their latest album.
Other artists have taken a similar approach.
The Charlatans made their latest album, You Cross My Path, available completely free on their own website.
Meanwhile, Madonna has signed a deal with Vodafone to make her new album, Hard Candy, available on mobile phones from 21 April, a week before it goes on sale in the shops.