Def Leppard went on a world tour with Whitesnake last year
Def Leppard are among four new acts to be added to this year's Download Festival bill.
The band will be headlining the main stage alongside Slipknot, while Whitesnake are set to return to Donington Park for the fourth time.
The other two acts announced for the event, which takes place between 12-14 June, are the recently reformed Limp Bizkit and US heavy metallers Trivium.
Other bands already on the bill include The Prodigy and Motley Crue.
Pendulum, Korn, DragonForce and Devildriver are also confirmed to appear.
The rock festival, which is now in its seventh year, will see performances from around 100 bands.
Previous headliners at the event have included System of a Down, Metallica and Black Sabbath.
Tickets are available from 9am on 13 February.