The Great North 10k started and ended at the Stadium of Light
The BUPA Great North 10k will move 10 miles north-west to Gateshead after two successful years in Sunderland.
Gateshead International Stadium will be the new home of the Great North 10k and will take place later this year.
The 10k run replaced the Great Women's Run which took place in Roker when it was opened up to male as well as female runners in 2009.
Sunderland City Council is at an "advanced stage" of hoping to launch a new 10k run in the summer of 2011.
The Great North 10k run was launched in 2009, evolving from the successful Great Women's Run, which took place for three years prior to that in Roker.
The 2009 run which started and ended outside the Stadium of Light was started by Olympic boxer Tony Jeffries from Sunderland.
In 2010 more than 5,000 people took part in the run, making it the North East's second biggest running event after the Great North Run.
This isn't the end of the road for 10k runs in Sunderland though.
Councillor Denny Wilson from Sunderland City Council explained: "Plans for the new event, which will take place in the summer, are at an advanced stage and an announcement to confirm the details will be made soon.
The start line of the final Great Women's Run in 2008
"This means that everyone, from the city and surrounding areas, who has enjoyed taking part in Sunderland's 10k run events in the last few years will be able to do so again in 2011, over a similar course that will take in the city's centre, parks, riverside, coastline and seafront."
Nova International, who organise the Great North 10k, made the decision to move the run from Sunderland to Gateshead.
Lynsey Stephenson from Nova International said: "We have enjoyed two excellent and very successful years in Sunderland where the event has grown in numbers with over 5000 runners.
"The Bupa Great North 10k, since its inception and as the name suggests was developed as a regional event with the potential to move around the North East.
"We feel the time is right to move to another part of the region and Gateshead is the perfect venue, enjoying a rich history of athletics and great infrastructure in the form of Gateshead International Stadium where the event finishes."
Great North 10k
The stadium is home to Gateshead College's Academy for Sport
Subject to the relevant approvals the new course for the Great North 10k will start outside Gateshead International Stadium.
The runners will pass notable landmarks such as BALTIC Centre for Contemporary Art, The Sage Gateshead, Gateshead Millennium Bridge and the Tyne Bridge.
It is also expected they will then follow the river west, past the old Garden Festival site, Gateshead Town Centre, past the Civic Centre before finishing back in the Stadium.
Gateshead Council cabinet member for culture councillor Linda Green said: "Bringing this prestigious event to Gateshead further cements our place at the forefront of athletics not only in the North East but also nationally.
"The course looks like it's going to be a challenging one, but I'm sure it's going to be a rewarding one."