The 2009 race attracted around 3,200 entries
The race returns for the sixth year running where serious athletes, fun-runners, fundraisers and families can take part.
The event, which is happening on Sunday 5 September, is one of the most popular 10k's in the north of England as numbers have increased every year.
Demand for the 5,000 places is expected to be high and runners can apply at the 10K site until Tuesday 31 August.
The 2009 race attracted around 3,200 entries.
3K fun run
The course for the 10k run is one lap, on flat roads and marked at each kilometre. Plus with full road closures, the run is ideal for all including those attempting a personal best.
The organisers have suggested exercise plans which last for eight weeks, and recommend that runners start their programme as early as possible to allow time to build up fitness and possibly progress on to another level.
There is also the Middlesbrough PCT 3k Fun Run is which takes place before the Middlesbrough 10k, setting off from the avenue of trees on hall drive in Acklam.