Thursday is the halfway point of In The City and the night-time festivities opened with the quirkily named Beans On Toast in the bar at Moho Live.
Round the corner at Soup Kitchen, the bright young folky thing that is Thomas J Speight got in on the act early.
Down on Dale Street, the opening responsibilities fell to Dublin alt-rockers, The Chakras, at Umbro Design Studio.
Back at Moho Live, the main room had joined in on the action, with a set from local four piece, The Tapestry.
Meanwhile, at Umbro Design Studio, it was the turn of London singer-songwriter Aaron Wright to show off his new backing band, The Aprils, and the fuller sound they have given him.
Up on Oldham Street, The Castle continued to be busy for a second night, with Icelandic post-rockers For A Minor Reflection providing a big sound for the small back room.
In a hat reminiscent of a certain Mancunian singer-songwriter, Holden’s frontman caught the eye at Umbro Design Studio.
Equally eye-catching, though for more colourful reasons, were Picture Book, who graced the stage of Mint Lounge.
Visually a little less vibrant, though much more so aurally, Japanese Voyeurs powered through a set at Night and Day.
At the same time across the Northern Quarter in Moho Live, Danny Mahon showcased his tunes with the help of a newly formed full band, which included ex-Twisted Wheel man, Rick Lees.
Proceedings closed at Umbro Design Studio on Dale Street with the set of Ellen and the Escapades, a group of alt-folkers who have already played the BBC Introducing stage at Reading and Leeds.
Leeds’ Sky Larkin provided a solid set over on High Street at The Ruby Lounge.
At the other ‘lounge’ venue, Mint Lounge, it was the turn of pop-dance band Diagram Of The Heart, who are the first signings to the newly resurrected Deconstruction Records.
Back on Tib Street, the hotly-tipped Hull trio, The Neat, surged across the main stage at Moho Live.
One road down, on Oldham Street, White Ring gave what might have been the most striking performance of the night at Dry Live.
Meanwhile, closing the night at Gullivers, local four piece Egyptian Hip Hop looked worth their growing hype, despite a late start. The shows on day two of In The City took place in Manchester's Northern Quarter.