First Minister Carwyn Jones described the recent media coverage of the child abuse claims in north Wales as "bordering on hysteria" on 13 November 2012.
He also warned that "the events from last week will discourage people from coming forward not only in relation to Bryn Estyn but other homes too" which will in turn "make it more difficult to get to the truth".
Plaid Cymru AM Leanne Wood raised questions over the number of reports into the sexual abuse as she warned that so many different inquiries could make it easier for people to cover their tracks.
She also called on the first minister to ensure that the children's commissioner is sufficiently resourced so that "vulnerable children will not fall through the gap".
Opposition party leaders Andrew RT Davies AM and Kirsty Williams AM both raised concerns over the National Clinic Forum report into NHS changes.
A BBC Wales report found that the independent report criticising NHS changes in north Wales was rewritten after being submitted.
The failure will affect people's "confidence in independent reports" according to Mr RT Davies.
Mr Jones stressed that ministers had no involvement in changes to the report and that there was "no interference of any kind" by the Welsh government.
Ms Williams challenged the first minister and his health minster to "get a grip of the organisation".
The Conservaties have tabled an urgent question on the matter.
The first minister also answered questions on borrowing powers, asbestos in schools and the EU budget.
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