The creation of city regions to boost economic development in the south, may be to the detriment of other areas of Wales, according to a AMs from across the chamber.
Business and Enterprise Minister Edwina Hart was making a statement on the City Regions Task and Finish Group Report, on 11 July 2012.
The report recommends the creation of two "city regions" in South East Wales and Swansea Bay to help boost economic development.
Economic growth increasingly happens in regions centred on a city, according to international research.
Populations of more than 500,000 attract higher skilled and better paid jobs.
Edwina Hart said: "We cannot deny the importance of our cities.
"Global trends show increasing urbanisation and Wales is very much a part of that.
"If there is an opportunity to take advantage of this to promote jobs and growth in Wales, then I will do so."
However Plaid Cymru's economy spokesperson Alun Ffred Jones warned that other areas across Wales may be ignored and would financially lose out, as a result of these plans.
On behalf of the Liberal Democrats, Eluned Parrott said that there will be "raised eyebrows" towards the focus on the south.
Labour AM for Delyn Sandy Mewis also asked the minister to consider improving transport networks, so that the whole of Wales could benefit from these plans.
Conservative AM for Clwyd West Darren Millar also voiced his concerns with regards to the focus on South Wales and the possibility of the north east "falling behind" the rest of Wales.
Responding to the members' comments, the minister agreed that these issues needed to be considered carefully.
However Mrs Hart underlined that these plans would also benefit other areas of Wales, such as the Valleys.