The UN is calling for rules to stop the companies going to the continent - one of our last unspoilt wildernesses - and having a "free for all".
They're after stuff like a natural anti-freeze which is found in some types of Antarctic fish.
Drug companies could use this to lengthen the shelf-life of frozen food.
They also think the Antarctic contains natural resources which could be used to treat cancer and other diseases.
The UN doesn't want to stop companies looking for new medicines which could benefit loads of people.
Pristine
But it thinks access to the area should be controlled.
"It's a pristine global park and it needs to be preserved," said a spokesman.
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