They told reporters that 107 people had been killed and at least 10 others were wounded in the Paktia province.
Lots of their houses had been destroyed too.
But officials in Washington have not admitted to the bombing yet.
The bombings have been going on even though the Taleban have surrendered, as the hunt for Osama Bin Laden and his al-Qaeda group - blamed for the 11 September attacks on the US - goes on.
The attack happened in the same area as the bombing earlier this month of a convoy of tribal leaders travelling to Kabul, who the US say were Taleban leaders.