The blue-haired cartoon character will make her broadcast from Springfield, and is expected to talk about the importance of families getting on.
Marge's 10-minute message will be shown on Channel 4 at 3pm on Christmas Day; the same time the Queen delivers her annual message on BBC1 and ITV.
Other celebs who have made the speech include Ali G and Sharon Osbourne.
The BBC used to broadcast The Simpsons on ordinary television, but from November the show will be on Channel 4 instead.
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