Steve and Karen McDonald will be in the thick of the action.
Steve, played by Simon Gregson, is set to help his dad, Jim, escape from prison. His mum, Liz, will also be making an appearance.
A Street spokesman said "sparks are set to fly" between Liz and Karen.
Among other Corrie stars making a comeback will be Bet Lynch, who used to be the pub landlady.
Millions of viewers watched Dirty Den return to EastEnders last month after a 14-year break.