The game has some added spice because the Rovers boss - Graeme Souness - is an ex-Rangers player-manager. He'll want to get one over his former Glasgow rivals.
Souness will be delighted to have striker Andy Cole and winger Damien Duff back from injury for the game.
And his probable strike partner Chris Sutton knows how to find the net at Ewood Park, having played their before his £10m move to Chelsea.
The second leg is on 14 November at Ewood Park.