They became the first UK school to link up by radio to the International Space Station and spoke to one of the astronauts on board.
The kids were so excited that some even came back from holiday just to take part.
The questions for Ed Lu ranged from "can you see our school from space?" to "when are we going to Mars?"
Neston school had been preparing for the event for almost two years.
Lessons there lately have included preparing mirrors for an actual satellite and putting on a space themed school play.
Nasa have even supplied the school with material for lessons.
Any school can apply to take part and a voluntary organistion called Amatuer Radio on the International Space Station (ARISS) provides the equipment.
To find out more, click on the ARISS link at the top right of this story.
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Read the transcript of their chat
Try the shuttles quiz
I talked to astronauts on a space station!
