Reading produced the first shock of the FA Cup fourth round by beating Premier League side Burnley 1-0 to boot them out of the competition.
Gylfi Siggurdsson netted a late winner after goalie Adam Federici made two great saves to stopped Burnley scoring.
Burnley are the second Premier League club Reading have beaten in the FA Cup. They beat Liverpool in the third round.
Meanwhile, Chelsea beat Championship side Preston 2-0 thanks to goals from Nicolas Anelka and Daniel Sturridge.
League One Leeds scored in the last minute to draw 2-2 with Spurs.
League Two side Notts County are facing a replay against Premier League Wigan after holding them to a 2-2 draw.
And Wolverhampton twice came back from behind to net a 2-2 draw and force a replay against Crystal Palace.
Elsewhere, Fulham, Aston Villa, Cardiff, Derby, Birmingham, Southampton, Portsmouth, Bolton and West Bromwich Albion all made it through to the fifth round.