Tottenham are out of the FA Cup after being beaten by Manchester United 2-1 at Old Trafford.
Former Spurs player Dimitar Berbatov scored the winning goal to seal United's place in the fifth round of the Cup.
Defending champions Portsmouth are also out of the competition after losing 2-0 to Championship side Swansea City.
Nathan Dyer, who is on loan to Swansea from Pompey's rivals Southampton, put the visitors ahead 26 minutes in.
Jason Scotland then doubled their lead with a goal from the spot on the stroke of half time.
Kettering and Torquay out
Kettering's John Dempster misses
Elsewhere in the competition, the two non-league sides that went into the fourth round have both been knocked out.
Fulham scored two goals in two minutes to beat Kettering 4-2.
And a late goal from Coventry City's Elliott Ward was enough to break Torquay United fans' hearts and secure Coventry a 1-0 victory and a place in the fifth round.
Villa held to draw
Championship side Doncaster Rovers held Aston Villa 0-0 and Burnley held West Bromwich Albion 2-2.
Meanwhile there were wins for Chelsea, Hull, West Ham, Sheffield United, Middlesbrough and Watford.