Rio Ferdinand will miss England's match with Andorra with a back injury, as they try to reach the 2010 World Cup.
All of the home nations are in action on Saturday, as the qualifying campaign for the tournament begins.
England kick off at 7pm against Andorra, who are ranked 186th in the world, so it will be a huge shock if they aren't well beaten.
Scotland, Wales and Northern Ireland face much tougher tests, against Macedonia, Azerbaijan and Slovakia.
Scotland will be playing in really hot conditions early in the afternoon away to Macedonia, and will be desperate to qualify.
They just fell short of making it to Euro 2008, and this time will want to go that little bit further.
Home nations matches
Macedonia v Scotland - 2pm KO
Wales v Azerbaijan - 3pm KO
Slovakia v Northern Ireland - 4.30pm KO
Andorra v England - 7pm KO
Northern Ireland also had a really good go at making it to the European Championship earlier this year, finishing third in their group.
That wasn't good enough to see them through, and the team will need loads more goals from their top striker David Healy, who grabbed 13 goals in 11 games in qualifying for Euro 2008.
When Wales take to the field in Cardiff against Slovakia they will be battling a lot of injuries as well as their opponents.
Two of their best strikers Freddy Eastwood and Craig Bellamy are injured, as well as three of their top defenders.
The Republic of Ireland are also action on Saturday, away to Georgia.