British hip-hop star Estelle has gone straight to number one with her latest track, ending Duffy's five-week reign at the top of the UK singles chart.
American Boy, featuring Kanye West, has pushed Duffy's Mercy to number two.
But there's some good news for the Welsh warbler - Rockferry is topping the album chart for its third week.
Back in the singles chart, the only other new entry to break into the top 10 was Madonna's 4 Minutes, featuring Justin Timberlake, in at number seven.
Leona Lewis slipped one place to three with her double A-side for Sport Relief - Better in Time and Footprints in the Sand.
There were eight new entries in the album chart, the highest of which was Muse's Haarp which went straight in at number two.