Wayne Rooney has told Sportsround he's hoping to "get a goal or two" when he plays his first game for England since being sent off in the World Cup.
The Man United star was suspended for England's first two qualifying matches for Euro 2008, but he can play against Macedonia on Saturday.
While England are expected to win, Scotland face a much tougher challenge when they host France.
Wales, Northern Ireland and the Republic of Ireland are also in action.
France were beaten in the final of the World Cup after Zinedine Zidane was sent off, and he has now retired from football.
But even without him, France have been playing well - winning both of their matches in Group B.
Home nation games
Wales v Slovakia
England v Macedonia
Scotland v France
Cyprus v Republic of Ireland
Denmark v Northern Ireland
Scotland have also got two wins from as many games, and welcome back captain Barry Ferguson into midfield.
Northern Ireland will also be hopeful of a good result, having caused a huge shock when they beat Spain in their last qualifier.
This time they play Denmark, who won their first qualifying match against Iceland.
After losing their first qualifying match, Wales will need a win when they host Slovakia in Cardiff.
Liverpool striker Craig Bellamy will captain Wales for the first time, although Wales do have injury problems with some of their defenders.
The Republic of Ireland are also in that group, and will expect to win when they travel to Cyprus.