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Tuesday July 26 2005 19:26 GMT
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In Pictures: Discovery takes off
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The crew are led out by pilots James Kelly and commander Eileen Collins.
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The Discovery blasts into space on Tuesday in Cape Canaveral, Florida, USA.
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"Three, two, one - and lift-off!"
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The shuttle is taking food to the International Space Station (ISS).
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The 12-day mission will be the first by a space shuttle since the Columbia orbiter broke up killing all seven astronauts on board in February 2003.
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Some 150,000 people weathered a really hot early morning to watch the launch.
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The launch date for Discovery was delayed by 13 days after a problem was detected with the fuel sensor.
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Discovery is due to return to Earth on the morning of 7 August.
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President George W Bush's wife, Laura, and brother the Florida Governor were among those watching.
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Discovery space shuttle takes off
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