The controversial US star was named best male artist, best hip-hop artist and was also rewarded for best album.
In the best hip-hop category he beat off competition from the host of the awards, P Diddy.
She was very pleased and told the 12,000 strong crowd in the Saint Jordi palace Barcelona: "A few years ago, it seemed that 'pop' was a dirty word. No longer."
Jennifer Lopez stopped Kylie from grabbing three prizes, when J-Lo scooped the best female award.
The US nu-metallers also took the best hard rock award.
And twenty-one-year-old Alicia Keys won the best R&B prize.
Eminem, Pink, Christina Aguilera, Robbie Williams, Foo Fighters, Bon Jovi and Coldplay all performed live for what P Diddy called "the biggest party in the world."