Different drugs have different effects on your body.
Drinking too much alcohol can lead to alcohol poisoning and liver failure, which can kill.
Smoking can cause lung and mouth cancer, and serious heart and stomach problems.
Illegal drugs can cause things like hallucinations (seeing strange things), sickness, depression, liver and kidney problems and fits. Some illegal drugs can kill the first time the person takes them.
Taking too much of any drug is called an overdose. A serious overdose of almost any drug can kill you.