The Daily Telegraph reports that only 150 are left in the Afghanistan region, part of an estimated total population of 5,000.
The International Snow Leopard Trust, based in the United States, is to report on its concerns about the snow leopard's survival.
Conservationists are trying to establish "safety corridors" so that snow leopards in one threatened area can travel to safer habitats.
One major problem for the snow leopards in Afghanistan has been the number of land mines left behind after decades of war.