The trustees of a cancer charity say they have been forced to dissolve it because of struggles to raise money during the recession.
Cancer Care Cymru funded specialist cancer nurses who work alongside NHS staff in Welsh hospitals.
But it said: "The present economic downturn has had a material effect on fundraising activities."
It added it will be working with its nurses and NHS Trusts to provide alternative arrangements for patients.
In a statement, the charity, which was launched in October 2005, said it was with "profound regret" that the trustees had decided to dissolve it immediately.
"As a non-publicly funded charity we have been totally reliant on income from benefactors and fundraising in the corporate and private sectors," it said.
"The present economic downturn has had a material effect on fundraising activities, leaving trustees with no alternative other than to take this course of action.
"The charity will be dissolved with immediate effect, but will be working with nursing staff and NHS Trusts over the next 12 weeks to endeavour to put in place alternative care arrangements for the cancer patients and their families who will be affected by the charity's closure.
"The trustees wish to thank everyone associated with the charity for their hard work and loyalty over the past four years."
On its website, the charity said it had been "developed specifically to provide information, support and care for people in Wales affected by cancer".
It said it had a team of 14 specialist nurses working at Velindre Hospital and the University Hospital of Wales in Cardiff, the Royal Glamorgan Hospital in Rhondda Cynon Taf, Llandough Hospital in the Vale of Glamorgan, the Princess of Wales Hospital, Bridgend and at Singleton Hospital, Swansea.
It also said it had staff based at Velindre Cancer Centre, who have responsibility for in-patients, along with a nurse who is mainly based at its headquarters in Cardiff Gate who works as the charity's professional development manager.