Up to 1,400 jobs are under threat at Birmingham City Council.
The posts, classed as "at risk", are all in the children, young people and families department and House of Sport, the strategic sports department.
Social care staff are not affected, the council said. Unions said they were shocked by the news.
A council spokesman said the move was a response to "current financial pressures". Up to 800 job cuts were announced last October.
'Mitigate job losses'
Staff are meeting council officials on Friday.
In a statement, a spokesman said: "The city is taking a structured and strategic review through our workforce planning to respond to our current financial pressures.
"Through this planning framework we'll review and look to mitigate job losses where we can.
"We have got a framework to control the financial situation the city council faces."