Six department stores in Norfolk, Suffolk and Essex are to close within four weeks after its new owner went into administration.
Department store owner Vergo Retail announced the six were among nine of its loss-making stores which would close, resulting in 335 redundancies.
Vergo acquired stores from the East of England Co-op in July 2009.
Stores in Norwich, Stowmarket, Clacton, Colchester, Witham and Dovercourt are among those that will shut.
Robbs of Hexham, Joblings in Sunderland and Derrys in Plymouth are also closing.
A decision to close Vergo's flagship store, Lewis's of Liverpool, was made earlier this year after a financial review of the group.
Administrators said a purchaser for the nine stores will not be ruled out until they stop trading.
Sarah Bell, partner at administrators MCR, said it was deemed that the nine stores were loss-making and would close within the next four weeks.
She added: "There is an opportunity for interested parties to come forward and rescue the remaining business as a going concern."