The Trinity Mirror newsgroup has announced job cuts and office closures on Tyneside and Teesside.
Up to 30 jobs will go and five offices are to shut as the company battles "challenging" trading conditions.
The firm publishes The Journal, Evening Chronicle and Sunday Sun from Newcastle and Evening Gazette from Middlesbrough.
Editorial offices in Stockton, Redcar, Guisborough, Durham and North Shields will close. The company said it hoped to find volunteers for redundancy.
The news follows similar moves at other Trinity Mirror centres across the country and comes in the face of dwindling advertising revenue.
Regional managing director Steve Brown said: "Today we announce a series of proposed measures to ensure that our companies in the North East ride out this economic downturn and best position ourselves for when conditions improve.
"These proposals reflect the senior management team's determination to do the best thing for the business overall and to respond pragmatically to the exceptional economic circumstances that we are now facing."
Graeme King, National Union of Journalists representative, said industrial action was a possibility.
He said: "Our top priority is to look after our members as they face up to the possibility of losing their jobs.
"We are prepared to talk to the company about the plans they have put forward, but we have very serious concerns about increasing workloads, and the quality of the editorial we will be able to produce, should these job cuts go ahead. We will take action if necessary."
Twenty three of the 28 job losses announced are to come from editorial departments.
Trinity Mirror owns five national titles, including the Mirror and more than 150 regional newspapers and 200 websites.
The group employs more than 8,000 people in 150 centres across the UK.