One man died and 70 others were injured when a coach carrying migrant workers rolled down an embankment and overturned in Staffordshire.
The vehicle collided with a car, crashed through a wall and ended up in a garden in Alton, near Alton Towers theme park, just before 1800 BST.
Those aboard were from Poland, Latvia, Lithuania, Romania and South Africa.
Two people were flown to hospital and 29 others taken to hospital by road, ambulance officials said.
The man who died was 26 years old and from Poland, police said.
The passengers were reported to be living in the Peterborough area and to have been on a trip to Alton Towers.
Murray MacGregor, of West Midlands Ambulance Service, said the coach driver, a man from Lincolnshire, was also seriously injured.
Ch Insp John Maddox, from Staffordshire Police, said officers were trying to establish what caused the crash.
"The bus was coming down a steep hill towards the bridge at the bottom, and from what I can see at the scene, that bus has not managed to go round the bend, and has careered through a wall and down a drop into a garden," he said.
All people on the coach have been accounted for, he added.
The ambulance service said 44 walking wounded had been taken to Alton Towers for medical treatment.
Two air ambulances, 10 land ambulances, five rapid response vehicles and five fire engines were sent to the scene.
Ian Sloss, a spokesman for the Staffordshire Fire and Rescue Service, said the scene was very difficult.
"There's a bus in a difficult situation which crews have had to secure and obviously the crews are working very hard in difficult circumstances," he said.
Two of the seriously injured were flown from the scene, one to Selly Oak Hospital in Birmingham and one to University Hospital North Staffordshire.
Terri Peachey, whose garden the coach crashed into, said she heard a sound "like thunder" when the accident happened and found injured people "bleeding", screaming and "laying on the floor crying" in her garden.
"It all happened so quickly," she said, adding that the coach landed metres from her house.
Bradley Ford, who lives at the nearby Alton Bridge Hotel, told BBC News he had helped with casualties.
He said: "I heard this massive crash, rumble, of either crunching metal or what sounded to me initially as a thunderstorm as it was heavily raining before.
"Then after that we heard shouts and screams so we obviously put it down to a crash.
"When I got to the scene there was a bus overturned, it looked like it had ploughed into a car and then down a neighbour's driveway into the garden.
"It must have dropped about 20ft (6m). It was on a slope, it's diagonal, not head-first."
He added: "There were people climbing out of the fire exits on the bus. There were many walking wounded, all being seen to by the ambulance staff."
The collision happened on Station Road, between Alton and the theme park, which is about one mile away.
Margaret Grice, who lives near the scene, said some of the injured banged on her front door.
She said: "I went to the front door and there was... there was about 12 to 15 people, all crying hysterically, blood running down their faces and their arms and... they couldn't speak English but they were able to say "accident, accident" so at that point I then rang 999."
Martin Bredda, who lives close to the scene of the crash, described the road as "an accident waiting to happen".
"It's a narrow country road. It's mayhem, absolute mayhem. We had a torrential downpour of rain just before it happened.
"I was in the local pub when someone came in screaming for blankets and sheets.
"We all went to help but the area had been cordoned off by police."
The staff canteen at the theme park has been set aside to provide shelter and refreshments.
The park sent a minibus to the scene to collect anyone who had been released by the ambulance crews, a spokeswoman said.
The bus was not connected to Alton Towers, she added.
Did you witness the crash? Send us your eye witness accounts using the form below.
The BBC may edit your comments and not all emails will be published. Your comments may be published on any BBC media worldwide.