Four people have been charged with perjury in connection with the original investigation into the 1988 murder of Cardiff prostitute Lynette White.
Paul Atkins, 52, Mark Grommek, 48, Angela Psaila, 42, and Leanne Vilday, 37, had been trial witnesses.
Yusef Abdullahi, Tony Paris and Steven Miller - known as the Cardiff Three - spent two years in jail before their murder convictions were quashed.
In 2003, security guard Jeffrey Gafoor was jailed after admitting the murder.
Gafoor had stabbed Ms White to death in a flat above a betting shop in Cardiff's docklands on Valentine's Day 1988.
The Cardiff Three were jailed for her murder in 1990 but released on appeal two years later.
It took 15 years for her real killer to be caught with a breakthrough because of advances in DNA technology.
The four witnesses from the original investigation were charged with perjury on Tuesday at four separate police stations - three in south Wales and one in Gloucester.
They are due to appear in court on 5 March.
Six other people have been released from bail and South Wales Police say another 14 remain on bail pending further inquiries.
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