The Scottish Amicable brand will no longer exist
Scot Am, which has been dealing in savings, investments and pensions since 1826, was bought for £2.78bn by Prudential in 1997.
Set up in Glasgow, the West of Scotland Life Assurance Society took mutual status in 1833.
Changing its name to the Scottish Amicable Life Assurance Society, the new financial institution set itself up as west coast rival to the friendly societies attracting investment and helping business in Edinburgh.
The company retained its mutual status - owned by policyholders not shareholders - until its sale four years ago.
The demutualisation saw more than 1.1 million with-profits investors sell their stake for as much as £1,400 each.
A further 400,000 policy-holders were deemed to be ineligible for the windfall payouts.
Scottish Amicable manages assets of £14bn but it will now be completely swallowed up by the Prudential group, one of the UK's biggest financial companies, with total funds under management of around £144bn.
Purpose-built offices
All ScotAm's life and pensions products will now carry the Prudential name.
Hundreds of job losses are expected at the company's purpose-built offices close to the M9 motorway at Stirling.
The company began its relocation from Glasgow to Stirling in 1952.
A large purpose-built headquarters at Craigforth was completed in the late seventies and the old Glasgow head office eventually closed in 1996.
There are currently 2,592 employees at Scot Am's Craigforth office and a further 120 at a contact centre near Glasgow's George Square.
The company recently invested £15m in opening a new building on the Craigforth site for administration and services.