Tony Blair is to fly to Washington for talks with US President George W Bush, the White House has announced.
The meeting will take place on Thursday and the new Iraqi government and Iran's nuclear ambitions will be on the agenda, Mr Bush's chief spokesman says.
Downing Street said the UK prime minister would also make a speech on foreign policy during his visit.
It comes after Mr Blair visited Iraq to mark its first full-term government since the 2003 US-led invasion.
On the agenda would be "supporting the new Iraqi government, preventing Iran from acquiring the means to build nuclear weapons, bringing peace to the Middle East, ending the violence in Darfur, and promoting free trade", said Mr Bush's spokesman Tony Snow.
"The United Kingdom is a key ally and a resolute partner of the United States in addressing these and other global challenges," he said.
Downing Street said the meeting was part of "ongoing contact" between the prime minister and president.
Mr Blair will leave the US on Friday, said the spokesman.
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