The force said six people were killed last month, compared to 12 in December 2006. It also said the number of people injured had been cut by a quarter.
Sussex Police said the figures showed its drink drive campaign in December had been a big success.
Of the 3,063 motorists tested during the campaign, 238 tested positive, 7.7% fewer than for the same period in 2006.
'Making an impact'
Supt Paul Morrision, head of the road policing unit, said: "The campaign is making an impact. The focus is on educating drivers rather than taking away their licences.
"I am delighted that the vast majority took heed - with many reporting their suspicions of fellow motorists to us too.
"Not only did it lead to a more enjoyable festive period, but there was a significant reduction in the number of people seriously injured or killed on the roads, which is a force priority."
He added: "However, there remains a small hardcore of drivers willing to risk everything by drinking and driving.
"We will continue the drink-drive campaign in Sussex into the new year in our efforts to keep the numbers of people being killed or seriously injured on our roads down."
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