Cars used by staff such as occupational therapists and dieticians to visit patients in Suffolk are being replaced with environmentally-friendly models.
Ipswich Hospital said it hoped to reduce carbon emissions by cars by 30% and to save £75,000 over four years.
Dave Mustoe, head of procurement, said: "The first cars have just arrived and everyone is pleased to be making a difference.
"As well as having lower emissions, the cars are also more fuel-economic."
Several departments in the hospital are using the cars.
They include pharmacy staff who visit care homes, community midwives and outreach nursing staff.
Mr Mustoe said: "Colleagues who have responded so far are looking at low emission vehicles and we are confident this will be a success story."
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