Campaigners created "human red ribbon" around Oxford's Radcliffe Camera to show their solidarity with the millions of people living with HIV/Aids.
The event was organised by Oxford University Stop Aids Society, ahead of World Aids Day on Monday, to highlight the plight of sufferers.
People who took part in the stunt on Saturday wore red as they held hands around the monument.
Those involved in the fight against HIV/Aids also made several speeches.
Agnes Granroth, co-chair of Oxford University Stop Aids Society, said: "With World Aids Day coming up this Monday, it is important that that we come together to show solidarity to remember those who have died of Aids and those who continue to be affected by HIV and Aids .
"This is not a protest. We just want to highlight the need to come together to raise awareness of HIV and Aids issues."
Figures show more than 22 million people have died from Aids and more than 42 million people are living with HIV/Aids across the world.
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