A Belgian frozen foods company plans to close its plant in Grantham, Lincolnshire with the loss of 42 jobs.
Pinguin bought the site at Easton in 2007, but said the decision to close it has come after a review of their frozen vegetable business.
A spokesperson said it would offer the workers a redundancy package.
The GMB union said the latest job losses would have a devastating effect on the local economy as 1,000 workers have lost their jobs recently.
Pinguin's Bernard Brown said the firm planned to shut the factory at the end of December and was consulting with unions about the closure.
GMB spokesman Andy Fletcher said: "There's a real risk that without funding to provide support and training to those who have lost their jobs, many will struggle to find work again."
In August, 700 workers lost their jobs at Northern Foods' Fenland Foods factory in Grantham.
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