A man was seriously injured when the car he was travelling in hit a central reservation barrier.
The man, 29, from Colchester, Essex, was a passenger in a Renault Clio which was involved in the crash on the A12 near the Ardleigh turn-off at 0150 BST.
He was taken to the Royal London Hospital with head injuries where he was described as being in a serious but stable condition.
The woman driver, 24, of Ipswich, Suffolk, suffered a broken arm.
Police have appealed for any witnesses to the accident to contact them.
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