Southampton was the home port of the Titanic
Miss Dean is unveiling a plaque at the former headquarters of the ship's owners, the White Star Line, in Canute Road, Southampton, on Monday.
Miss Dean, who is believed to be one of only four survivors still alive, was only nine-weeks-old when the ship sank.
More than 1,500 people died in the freezing Atlantic when the "unsinkable" vessel hit an iceberg on 15 April 1912.
Southampton was the home port of Titanic and the unveiling will mark the building as a site of historic significance.
The event is the last of a series in Southampton to mark the anniversary of the sinking.
On Sunday there was moving open-air commemorative service at the Titanic Engineers' Memorial.
Southampton mayor Christine Kelly laid a wreath in memory of the 549 people from the city who died on the liner.
Miss Dean, who lives in the New Forest, was central to the anniversary.
She opened a revamped exhibition of the Titanic at Southampton's Maritime Museum and even launched web pages on the tragedy.
Miss Dean's father Bertram drowned when the Titanic sank but her mother Georgetta and elder brother Bertram junior were rescued.