The two-and-a-half hour procession was held at the Gurdwara Sri Guru Singh Sabha temple in Southall, Middlesex - the largest Sikh temple in Europe.
It is actually marked on 13 and 14 April, but processions are held throughout the Sikh world on various dates beforehand.
The Southall procession, called Nagar Kirtan, was led by five "panj piaray", dressed in traditional yellow and representing the first five members of the Khalsa.
Carried at the head of the procession, on an ornate bejewelled float, was the revered Sikh Holy book.
Behind, members of the Sikh community, dressed in ordinary clothes but all with their heads covered and many barefoot, chanted prayers.
BBC correspondent Martha Doyle, at the festival, said there was an atmosphere "of both celebration and reverence".
She said it was notable for the numbers of young people turning out for the devotions.
Across Britain
Sikhism was founded by Guru Nanak in 1469, and the Khalsa - the core community of committed followers within the wider Sikh faith - in 1699.
It was founded when the 10th Guru, Gobind Singh, gathered Sikh devotees together during the Punjab harvest festival and baptised them.
Vaisakhi (also spelled "Baisakhi") processions have been held in Southall since the 1960s. This year's procession was the biggest in Europe.
Other processions were held at temples throughout Britain, which is home to about 500,000 Sikhs.