The ceremony in Westminster Hall will be broadcast live on BBC Two and BBC Radio 4.
Britain's first Holocaust Memorial Day takes place on Saturday, timed to coincide with memorial days in Germany, Italy and Sweden.
A ceremony in central London, at 2000GMT, will include speeches by Prime Minister Tony Blair and the leader of Britain's Jews, Chief Rabbi Jonathan Sacks.
The ceremony in Westminster Hall will be broadcast live on BBC Two and BBC Radio 4.
As well as the Holocaust, there will also be recognition of genocide in Cambodia, Rwanda and Bosnia-Herzegovina, but the Turkish massacre of thousands of Armenians in 1915 will not be included.
The day of remembrance marks the anniversary of the liberation of the Auschwitz concentration camp on 27 January, 1945.
Home Secretary Jack Straw said in a statement: "Holocaust Memorial Day is intended as an inclusive commemoration of all the individuals and communities who suffered as a result of the Holocaust - not only Jews, but also gypsies, Slavs, homosexuals, political prisoners and dozens of ethnic and other minorities.
"The day will put a particular emphasis on educating people of all ages about the lessons to be learnt from genocide."
Prince Charles will light a candle and hear accounts from Holocaust survivors.
Auschwitz survivor Naomi Blake, now a successful sculptress, told BBC News 24: "I feel the only thing we have is to remember. Then we know and are prepared if it happens again."
Scottish ceremony
Home Secretary Jack Straw, Tory leader William Hague, Liberal Democrat leader Charles Kennedy and the leaders of all Britain's main churches will attend the ceremony.
Survivors of Nazi concentration camps will be in attendance, as will survivors of other atrocities.
From the Armenian community in Britain, its church's spiritual leader here, the Right Reverend Nathan Hoviharnissian, will be in attendance.
There have been protests about the remembrance day from some Armenians, who feel their suffering is still being ignored.
The Armenians were the victims of what they say was genocide by the Ottoman Empire between 1915 and 1917.
They estimate the Turks wiped out between 1.1 million and 1.8 million out of a population of 2.8 million, but the issue is hugely sensitive and the facts remain in dispute.
A separate Scottish event will be held at the Usher Hall in Edinburgh.
Scottish First Minister Henry MacLeish and the Secretary of State for Scotland, Helen Liddell, will be in attendance at the event which will include a broadcast of Richard Dimbleby's famous BBC radio broadcast at the liberation of Belsen camp.
Countrywide events
Other events have been organised all over the country for what will become an annual event.
Officials in Gloucestershire held a memorial service with readings, and signed a Statement of Commitment on Saturday.
In Leeds a ceremony of remembrance and a one-minute silence will be held in Victoria Gardens on Sunday, followed by a candle-lit procession to the Civic Hall.
A free exhibition commemorating innocent victims murdered in the last 100 years is opening at Carmarthenshire County Museum, south Wales, with children across Torfaen planting commemorative snowdrops for those who died or were persecuted in the Holocaust.
Residents of Cardiff came together at a special National Memorial Service at Cardiff City Hall on Friday night with a multi-faith service at the Temple of Peace on Sunday.
On Saturday morning, the Chancellor Gordon Brown honoured a minute's silence in memory of the Holocaust victims at a Fabian Society conference in London.